The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 03, 1996
Filed:
Sep. 23, 1994
Applicant:
Inventors:
Bhanu Rajput, College Park, MD (US);
Bhabatosh Chaudhuri, Munchenstein, CH;
Fredericus A Asselbergs, Riehen, CH;
Bernd Meyhack, Magden, CH;
Jutta Heim, Ramlinsburg, CH;
Jan van Oostrum, Fluh, CH;
Sefik Alkan, Riehen, CH;
Assignee:
Ciba-Geigy Corporation, Tarrytown, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424 9463 ; 424 9464 ; 435212 ; 435215 ; 435226 ;
Abstract
Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.