The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 26, 1996
Filed:
Apr. 08, 1994
Ching T Chang, Taipei, TW;
Ching-Jer Chang, West Lafayette, IN (US);
Chen-Tao Lee, Hsinchu, TW;
Fen-Lan Lin, Hsinchu, TW;
Jih-Dar Tsai, Hsinchu, TW;
Curtis L Ashendel, West Lafayette, IN (US);
Thomas C Chan, Hopkinton, MA (US);
Robert L Geahlen, West Lafayette, IN (US);
David J Waters, West Lafayette, IN (US);
Purdue Research Foundation, West Lafayette, IN (US);
International Technology Research Institute, Hsinchu, TW;
Abstract
Novel polythiophene compounds useful as anti-tumor agents are described. Preferred compounds of the formula: ##STR1## wherein n is 0-2 and R.sub.2 and R.sub.3 are optionally substituted 2-thienyl or 3-thienyl have been found to exhibit selective cytotoxic activity against transformed human cells. Pharmaceutical compositions containing the described polythiophene compounds are expected to exhibit good chemotherapeutic activity against slow growing tumors based on tumor cell line assays. A method for treating patients having tumors utilizing the disclosed polythiophene compounds is also described.