The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 19, 1996
Filed:
Aug. 29, 1994
Applicant:
Inventors:
Thorsten E Fisher, Hatfield, PA (US);
John S Wai, Harleysville, PA (US);
J Christopher Culberson, Hatfield, PA (US);
Walfred S Saari, St. George, ME (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
514211 ; 514217 ; 5142222 ; 5142278 ; 5142288 ; 514 315 ; 514241 ; 514247 ; 514256 ; 514290 ; 514307 ; 514311 ; 514314 ; 514315 ; 514316 ; 514317 ; 514318 ; 514318 ; 514320 ; 514321 ; 514322 ; 514323 ; 514324 ; 514326 ; 514330 ; 540519 ; 540524 ; 544 14 ; 544 55 ; 544 60 ; 544111 ; 544224 ; 544233 ; 544238 ; 544245 ; 544338 ; 544359 ; 546 79 ; 546139 ; 546148 ; 546149 ; 546152 ; 546187 ; 546189 ; 546193 ; 546195 ; 546196 ; 546197 ; 546198 ; 546200 ; 546201 ; 546205 ; 546207 ; 546208 ; 546209 ; 546210 ; 546212 ; 546214 ; 546226 ;
Abstract
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer.