The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 1996
Filed:
Jun. 15, 1994
Michitaka Zushi, Numazu, JP;
Komakazu Gomi, Kawasaki, JP;
Shuji Yamamoto, Fuji, JP;
Koji Suzuki, Tsu, JP;
Akio Matsuda, Fuji, JP;
Asahi Kasei Kogyo Kabushiki Kaisha, Osaka, JP;
Abstract
Disclosed is a substantially pure polypeptide having a specific amino acid sequence containing (a) an amino acid residue selected from the group consisting of Asp, Glu and Gla wherein Gla represents a .gamma.-carboxyglutamic acid residue or (b) a peptide or polypeptide residue consisting of at least two amino acid residues selected from Asp, Glu and Gla, wherein the above-mentioned at least two amino acid residues are all the same or combinations of the Asp, Glu and Gla. The polypeptide is capable of interacting with thrombin to form a binding therebetween, thereby exhibiting an activity to inhibit the blood coagulation and platelet aggregation by thrombin and/or an activity to promote the thrombin-catalyzed activation of protein C. This novel polypeptide has a low molecular weight so that it is suitable for oral or nasal administration.