The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 1996
Filed:
Dec. 21, 1993
Tsutomu Kurokawa, Kawanishi, JP;
Ken-ichi Kuroshima, Osaka, JP;
Sumie Yoshitomi, Osaka, JP;
Chisako Seko, Osaka, JP;
Takeda Chemical Industries, Ltd., Osaka, JP;
Abstract
The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced. Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.