The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 05, 1996
Filed:
May. 11, 1994
Applicant:
Inventors:
Tsuneya Ohno, Boston, MA (US);
Ralph R Weichselbaum, Chicago, IL (US);
Donald W Kufe, Wellesley, MA (US);
Assignee:
Arch Development Corporation, Chicago, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ;
U.S. Cl.
CPC ...
514 44 ; 424-111 ; 424-149 ; 424-161 ; 424-165 ; 424-169 ; 424450 ; 424 932 ; 424 9321 ; 4351723 ; 4353201 ; 435 691 ; 435 695 ; 536 241 ; 935-6 ; 935 34 ; 935 59 ; 935 62 ;
Abstract
The present invention provides a method for delivering ionizing radiation to specific tissues, resulting in the activation of a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. The radiation source may be will generally be in the form of a radionuclide, capable of gamma or beta emissions. Processes for regulating polypeptide expression and inhibiting tumor growth using such DNA molecules are also provided.