The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 1996
Filed:
Jan. 24, 1995
Sui-Ming Wong, Collegeville, PA (US);
Ian M Newington, Hazlemere, GB;
Elaine M Liversidge, West Chester, PA (US);
Gregory L McIntire, West Chester, PA (US);
Alan R Pitt, Sandridge, GB;
Jack M Shaw, Aberdeen, MD (US);
Nano Systems L.L.C., Collegeville, PA (US);
Abstract
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a block copolymer linked to at least one anionic group as a surface modifier adsorbed on the surface thereof and a method of making such nanoparticles. The compositions exhibit unexpectedly improved autoclave stability, reduced macrophage uptake, improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.