The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 22, 1996
Filed:
May. 05, 1995
Adir et Compagnie, Courbevoie, FR;
Abstract
Compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl or (C.sub.3 -C.sub.7) cycloalkyl R.sub.2 represents alkyl, or (C.sub.3 -C.sub.7) cycloalkyl, R.sub.3 represents hydrogen or alkyl, R.sub.4 represents halogen or alkyl or alkoxy, R.sub.5 represents alkyl, X and Y, which are different, represent CO or SO.sub.2, n represents 1, 2 or 3, p represents 0 or 1, Z represents sulfur or oxygen, A represents any one of the following groups: ##STR2## in which: A.sub.1 represents, with the nitrogen and carbon atoms to which it is attached, a mono- or bicyclic heterocycle, .cndot. or, ##STR3## in which: R.sub.6 represents hydrogen, alkyl or cycloalkyl or 2-indanyl, R.sub.7 represents hydrogen or alkyl, which compounds of formula (I) comprise thereof corresponding hydrates of the ketone function COCF.sub.3, the enantiomers, diastereoisomers and epimers thereof and the addition salts thereof with a pharmaceutically acceptable base and medical products containing the same are useful as HLE inhibitor.