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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5559005 B1

PDFFull Text
Date of Patent:
Sep. 24, 1996

Filed:

May. 27, 1994

Bioprocess for preparing 7-aca and 7-adac

Applicant:
Inventors:

Michael J Conder, Harrisonburg, VA (US);

Phyllis C McAda, Woodinville, WA (US);

John A Rambosek, Seattle, WA (US);

Christopher D Reeves, Woodinville, WA (US);

Assignee:

Merck & Co., Inc., Rahway, NJ (US);

Attorneys:

Meredith; Roy D.

Tribble; Jack L.

Primary Examiner:

Christopher S Low

Int. Cl.
CPC ...
C12P / ; C12P / ; C12N / ;
U.S. Cl.
CPC ...
435 47 ; 435 49 ; 435 51 ; 435183 ; 435230 ; 435243 ; 43525411 ; 4353201 ; 4351723 ; 4352545 ; 536 231 ; 536 232 ; 536 2374 ;
Abstract

Important intermediates for preparing cephalosporin antibiotics, 7-amino-cephalosporanic acid (7-ACA) and 7-aminodeacetylcephalosporanic acid (7-ADAC), are prepared by a novel bioprocess in which a transformed Penicillium chrysogenum strain is cultured in the presence of an adipate feedstock to produce adipoyl-6-APA (6-amino penicillanic acid); followed by the in situ expression of the following genes with which the P. chrysogenum has been transformed:

Find Patent Forward Citations

Conder, Michael. (1996). Bioprocess for preparing 7-aca and 7-adac (U.S. Patent No. 5559005). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5559005

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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