The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 1996
Filed:
Dec. 16, 1994
Henry W Pauls, Collegeville, PA (US);
Yong-Mi Choi, Jeffersonville, PA (US);
Robert W Studt, Reading, PA (US);
Martin P Maguire, Mont Clare, PA (US);
Alfred P Spada, Lansdale, PA (US);
Don D Cha, Eagleville, PA (US);
Rhone-Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA (US);
Abstract
This invention relates to a class of novel dicarboxy amide derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis-aryl and/or heteroaryl alkyl or cycloalkylamino dicarboxy amides. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.