The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 1996
Filed:
Jan. 10, 1994
Applicant:
Inventors:
James E Samuel, Germantown, MD (US);
Valery M Gordon, Kensington, MD (US);
Assignees:
MicroCarb, Inc., Gaithersburg, MD (US);
The United States of America as represented by the Secretary of the Army, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C07K / ; C12N / ;
U.S. Cl.
CPC ...
4242361 ; 4242411 ; 530350 ; 530825 ; 435200 ;
Abstract
Disclosed herein are immunogenic mutant Shiga-Like Toxin II variants and vaccines containing such toxins. The mutant toxin comprises an SLT-IIv where the amino acid at position 167 in the A subunit has been replaced by a differently charged amino acid that essentially maintains the structure of the native A subunit. In a preferred embodiment, the glutamic acid is replaced with glutamine. An analogous modification may also be made at position 170. The vaccines are used for edema disease of swine.