The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 1996
Filed:
Aug. 12, 1994
Applicant:
Inventors:
Karel J Lambert, San Diego, CA (US);
Edward G Jablonski, Escondido, CA (US);
Carl Hulle, San Diego, CA (US);
Assignee:
Molecular Biosystems, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ;
U.S. Cl.
CPC ...
424-952 ; 424-95 ;
Abstract
Encapsulated gas microspheres useful as an ultrasonic imaging agent are made by: mixing an aqueous solution of a heat-denaturable protein with a gas, and passing the gas-solution mixture through a mill whereby the mixture is emulsified near the denaturation temperature of the protein and subjected to mechanical shearing and cavitation which causes the formation of gas bubbles in the 0.1 to 10 micron range, and the protein to locally denature and deposit at the gas-liquid interface to form the encapsulated microspheres.