The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 1996
Filed:
Jun. 22, 1994
Bradley J Benson, Chapel Hill, NC (US);
Xiannong Chen, Athens, GA (US);
George J Cianciolo, Chapel Hill, NC (US);
Jose-Luis Diaz, Durham, NC (US);
Khalid S Ishaq, Chapel Hill, NC (US);
Susan L Morris-Natschke, Apex, NC (US);
Ronald J Uhing, Durham, NC (US);
Henry Wong, Morrisville, NC (US);
University of North Carolina, Chapel Hill, NC (US);
Macronex, Inc., Morrisville, NC (US);
Abstract
Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.