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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5548068 B1

PDFFull Text
Date of Patent:
Aug. 20, 1996

Filed:

Dec. 23, 1994

Somatotropins with alterations in the alpha-helix 1 region, and

Applicant:
Inventors:

Meir Fischer, Rehovot, IL;

Michael R Lebens, Gotenberg, SE;

Deborah T Chaleff, Mercer, NJ (US);

Assignees:

Bio-Technology General Corp., Iselin, NJ (US);

American Cyanamid Company, Wayne, NJ (US);

Attorney:

White; John P.

Primary Examiner:

Garnette D Draper

Assistant Examiner:

K Cochrane Carlson

Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
530399 ; 435 694 ;
Abstract

The present invention relates to somatotropin analogues with amino acid changes in the alpha-helix 1 regions of said somatotropins, alone or in combination with mutations in the alpha-helix 3 and/or alpha-helix 2 regions, plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptide also are provided.

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Fischer, Meir. (1996). Somatotropins with alterations in the alpha-helix 1 region, and (U.S. Patent No. 5548068). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5548068

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