The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 06, 1996
Filed:
Feb. 03, 1995
Applicant:
Inventors:
Ole Nordfang, Hillerod, DK;
Mirella E Rasmussen, Copenhagen, DK;
Assignee:
Novo Nordisk A/S, Novo Alle, DK;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; G07K / ; G07K / ; C12P / ;
U.S. Cl.
CPC ...
530383 ; 435 696 ;
Abstract
A coagulation active complex of Factor VIII fragments is produced by causing a coagulation inactive FVIII heavy chain to react with a coagulation inactive FVIII light chain in the presence of a complex forming agent. Thus, FVIII-HC and FVIII-LC are converted to coagulation active FVIII complex in the presence of metal ions, such as Mn.sup.2+, Ca.sup.2+, or Co.sup.2+ or a component of the prothrombin complex or a substance having reactivity to compounds containing the group --SH and/or --S--S.