Antifungal and anti-pneumocystis compounds, compositions containing such

Abstract

Compounds represented by the formula I (SEQ ID NO. 1) are disclosed: ##STR1## as well as pharmaceutically acceptable salts and hydrates thereof. R.sup.I represents C.sub.9 to C.sub.19 alkyl, C.sub.9 to C.sub.19 alkenyl, an aryl group which includes phenyl, biphenyl, naphthyl and terphenyl or a C.sub.1 to C.sub.12 alkyl, alkylamino, dialkylamino or alkoxyaryl group. R.sup.1, R.sup.2 and R.sup.4 independently represent H or --OH. R.sup.3 represents H, --OH, --O(CH.sub.2).sub.n NR.sup.V R.sup.VI, where R.sup.V and R.sup.VI independently represent H or C.sub.1-4 alkyl, or --O(CH.sub.2).sub.n NR.sup.V R.sup.VI R.sup.VII+ Y.sup.-, wherein R.sup.V and R.sup.VI are as defined above, R.sup.VII represents H or C.sub.1-4 alkyl, n is an integer of from 2-6 inclusive, and Y represents a counterion. R.sup.5 represents H, --CH.sub.3 or --OH; R.sup.6 represents H or --CH.sub.3 ; R.sup.7 represents H, --CH.sub.3, --CH.sub.2 C(.dbd.O)NH.sub.2, --(CH.sub.2).sub.2 NR.sup.V R.sup.VI or --(CH.sub.2).sub.2 NR.sup.V R.sup.VI R.sup.VII+ Y.sup.- with n, R.sup.V, R.sup.VI R.sup.VII and Y as defined above; and R.sup.8 represents --Cl, --Br, --I, --NO.sub.2, --N.sub.3, --(CH.sub.2).sub.0-4 NH.sub.2, --(CH.sub.2).sub.0-4 NH(C.sub.1-4 alkyl), --(CH.sub.2).sub.0-4 N(C.sub.1-4 alkyl).sub.2, --(CH.sub.2).sub.0-3 CH(.dbd.NOH), --NHC(.dbd.O)(CH.sub.2).sub.1-6 NH.sub.2 or --NHC(.dbd.O)(CH.sub.2).sub.1-6 NHC(.dbd.NH)(CH.sub.2).sub.0-3 H. Pharmaceutical compositions and methods of use are also disclosed.