The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 16, 1996
Filed:
Dec. 21, 1992
Richard T Evans, East Amherst, NY (US);
Gurrinder S Bedi, Bluebell, PA (US);
Robert J Genco, Buffalo, NY (US);
Hakimuddin T Sojar, Buffalo, NY (US);
The Research Foundation of State University of New York, Buffalo, NY (US);
Abstract
Polypeptides related to fimbriae of Porphyromonas gingivalis are described and claimed which exhibit inhibition of bacterial adhesion to saliva-coated surfaces. The polypeptides are selected from the group consisting of fimbriae, fimbrillin, and fimbrial-related. peptides derived therefrom. The polypeptides are used as active ingredients in various oral formulations designed to prevent adhesion of P. gingivalis to host mucosal surfaces and thus interfering with the development of periodontitis. The polypeptides are also used in subunit vaccine formulations for use against pathogenic, fimbriated P. gingivalis in the prophylactic treatment of periodontitis. Use of the polypeptides for inducing protective immunity in serum and gingival crevicular fluid may prevent primary infection with P. gingivalis as well as the spread of the organism between intraoral reservoirs.