The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 1996
Filed:
Jun. 05, 1995
Endre Palosi, Budapest, HU;
Dezso Korbonits, Budapest, HU;
Erzsebet Molnar nee Bako, Szodliget, HU;
Ida Szvoboda nee Kanzel, Dunakeszi, HU;
Gergely Heja, Budapest, HU;
Pal Kiss, Budapest, HU;
Csaba Gonczi, Budapest, HU;
Ferenc Sperber, Budapest, HU;
Csaba Huszar, Budapest, HU;
Gyorgy Mihalovics, Budapest, HU;
Attila Nemeth, God, HU;
Mihaly Su, Budapest, HU;
Karol Gyure, Fenyveslitke, HU;
Istvan Bone, Budapest, HU;
Ferenc Morasz, Budapest, HU;
Laszlo Ledniczky, Budapest, HU;
Erzsebet Szabo nee Kardos, Budapest, HU;
Peter Gy ri, Budapest, HU;
Erzsebet Szalay, Budapest, HU;
Karoly Ban, Budapest, HU;
Iidiko Buttkai, Budapest, HU;
Arpad K vari, God, HU;
Sandor Garaczy, Budapest, HU;
Aktiebolaget Astra, Sodertalje, SE;
Abstract
The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C.sub.1-5 alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.