The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 1996
Filed:
Dec. 10, 1993
Roland M Evans, La Jolla, CA (US);
Cary A Weinberger, Silver Springs, MD (US);
Stanley M Hollenberg, Seattle, WA (US);
Vincent Giguere, Etobicoke, CA;
Jeffrey Arriza, Carlsbad, CA (US);
Catherine C Thompson, La Jolla, CA (US);
Estelita S Ong, San Diego, CA (US);
The Salk Institute for Biological Studies, La Jolla, CA (US);
Abstract
The present invention provides methods for the controlled production of recombinant proteins in cells. Cells employed in the invention method contain a gene encoding the desired recombinant protein, with transcription of the gene maintained under the control of a transcriptional control element which is activated by a ligand/receptor complex. The ligand/receptor complex is formed when a ligand (which is a hormone or/and analog thereof) is complexed with a receptor (which is a hormone receptor or functional analog thereof which has the transcription activating properties of the receptor). Receptor is produced by the expression of non-endogenous DNA which is also present in the cells used for production of recombinant protein.