The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 09, 1996
Filed:
Mar. 10, 1994
Applicant:
Inventors:
Megan E Laurance, Portland, OR (US);
David Knaack, Chepachet, RI (US);
Deborah M Fiore, Swansea, MA (US);
Orion D Hegre, Chepuchet, RI (US);
Assignee:
CytoTherapeutics, Inc., Providence, RI (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12Q / ; C12P / ;
U.S. Cl.
CPC ...
435-3 ; 424 937 ; 435-721 ; 435 14 ; 435 30 ; 435 34 ; 435 35 ; 435 694 ; 435 703 ; 4352401 ; 4352402 ; 43524021 ; 436172 ;
Abstract
A method of selecting cells with enhanced secretion of a secretory product is disclosed. The method comprises exposing a population of cells to a secretagogue to result in the secretion of a secretory product from the cells and selecting from the population, cells that exhibit increased amounts of intracellular free calcium when exposed to the secretagogue. The method enables the selection of correctly regulated .beta. cells that secrete appropriate amounts of insulin in response to varying glucose levels.