The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 02, 1996
Filed:
May. 12, 1995
Applicant:
Inventors:
Mark Goulet, Westfield, NJ (US);
William H Parsons, Edison, NJ (US);
Helen M Organ, Fanwood, NJ (US);
Peter J Sinclair, Highland Park, NJ (US);
Frederick Wong, Glen Ridge, NJ (US);
Matthew J Wyvratt, Mountainside, NJ (US);
Assignee:
Merck Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514291 ; 540456 ; 540452 ; 514411 ;
Abstract
O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3' and/or C-4' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.