The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 25, 1996

Filed:

May. 18, 1994
Applicant:
Inventors:

Thomas Kramer, Wuppertal, DE;

Rudolf Hanko, Essen, DE;

Jurgen Dressel, Radevormwald, DE;

Peter Fey, Wuppertal, DE;

Walter Hubsch, Wuppertal, DE;

Ulrich Muller, Wuppertal, DE;

Matthias Muller-Gliemann, Solingen, DE;

Martin Beuck, Erkrath, DE;

Hilmar Bischoff, Wuppertal, DE;

Stefan Wohlfeil, Hilden, DE;

Dirk Denzer, Wuppertal, DE;

Stanislav Kazda, Wuppertal, DE;

Johannes-Peter Stasch, Solingen, DE;

Andreas Knorr, Erkrath, DE;

Siegfried Zaiss, Wuppertal, DE;

Assignee:

Bayer Aktiengesellschaft, Leverkusen, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514381 ; 548253 ;
Abstract

Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.


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