The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 1996
Filed:
Jan. 21, 1994
Adrian L Smith, Bishops Stortford, GB;
Chan-Kou Hwang, San Diego, CA (US);
Sebastian V Wendeborn, La Jolla, CA (US);
Kyriacos C Nicolaou, La Jolla, CA (US);
Erwin P Schreiner, Vienna, AT;
Wilhelm Stahl, Frankfurt am Main, DE;
Wei-Min Dai, Kowloon, HK;
Peter E Maligres, Scotch Plains, NJ (US);
Toshio Suzuki, Niigata, JP;
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The compounds have DNA-cleaving, antimicrobial and tumor growth-inhibiting properties. Chimeric compounds having the fused ring system compound as an aglycone bonded to (i) a sugar moiety as the oligosaccharide portion or (ii) a monoclonal antibody or antibody combining site portion thereof that immunoreacts with target tumor cells are also disclosed. Compositions containing a compound or a chimer are disclosed, as are methods of preparing a compound.