The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 18, 1996
Filed:
Aug. 20, 1993
Solomon R Eisenberg, Newton, MA (US);
Carlos M Samour, Newport, RI (US);
Macrochem Corporation, Lexington, MA (US);
The Trustees of Boston University, Boston, MA (US);
Abstract
New and improved method for the transdermal administration of agents is provided utilizing iontophoresis in conjunction with a water-insoluble, stratum corneum-lipid modifier. The lipid modifier may be used prior to iontophoresis or simultaneously therewith. The lipid modifier may be selected from a wide variety of moieties of the general formula R--X where R is a C.sub.5 to C.sub.28 alkyl or unsaturated alkyl and X is a member of the following: 1,3-dioxane; 1,3-dioxolane; lactam; morpholine; --COOH; --OH; --COOR'; --C--N(R').sub.2 ; cyclo ethylene and propylene carbonates; --CONH.sub.2 ; --(CH.sub.2 --CH.sub.2 O).sub.n H; ##STR1## acetals, and hemiacetals; and wherein R' is lower alkyl (e.g., C.sub.1 to C.sub.3) and n is an integer of from 1 to 20. Optionally there may be present a polar, water-soluble chemical compound from the group of alcohols, glycols, lactams, dioxolanes, esters, ureas, morpholine and the like. Compositions and articles useful in the processes of the present invention are also provided.