The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 1996
Filed:
Sep. 28, 1993
Applicant:
Inventors:
Christopher E Rudd, Cambridge, MA (US);
Prasad Kanteti, Boston, MA (US);
Assignee:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C07K / ;
U.S. Cl.
CPC ...
4352402 ; 530330 ;
Abstract
Disclosed are compositions and methods of blocking T cell signal transduction by introducing into a T cell a peptide comprising a PI 3-kinase-binding-sequence which decreases the association of PI 3-kinase with CD28. Also disclosed are compositions and methods of amplifying T cell activation by introducing into a T cell, a plurality of modified T cell surface proteins, the cytoplasmic tail of which comprises a plurality of copies of a PI 3-kinase-binding-sequence.