The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 11, 1996
Filed:
Oct. 20, 1993
Applicant:
Inventors:
John L Danssaert, San Diego, CA (US);
Robert J Shopes, San Diego, CA (US);
Daniel D Shoemaker, Stanford, CA (US);
Assignee:
Stratagene, La Jolla, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
B01L / ;
U.S. Cl.
CPC ...
422 99 ; 422 63 ; 422 67 ; 422104 ; 435809 ; 4352851 ; 4352861 ; 4352862 ; 4352884 ; 4353031 ; 935 85 ;
Abstract
A method in which a temperature gradient is generated across a 'gradient' block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient block can be simultaneously run at temperatures which differ only slightly, thereby permitting an optimum temperature for the reaction to be quickly identified. In a preferred embodiment the gradient block is integrated into a thermal cycler used for nucleic acid amplification reactions.