The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 21, 1996
Filed:
Jun. 07, 1995
Yuichi Hikichi, Suita, JP;
Takeo Moriya, Suita, JP;
Hiroshi Miki, Kobe, JP;
Takamasa Yamaguchi, Kobe, JP;
Ikuo Nogami, Nagaokakyo, JP;
Takeda Chemical Industries, Ltd., Osaka, JP;
Abstract
A method of producing D-pantothenic acid or a salt thereof characterized by bring a microbe belonging to the family Enterobacteriaceae having resistance to salicylic acid and capable of producing D-pantothenic acid in the presence of .beta.-alanine in contact with .beta.-alanine, preferably wherein a microbe resistant to .alpha.-ketoisovaleric acid and/or .alpha.-ketobutyric acid, and/or .alpha.-aminobutyric acid and/or .beta.-hydroxy-aspartic acid and/or O-methyl-threonine or a microbe transformed with a plasmid DNA carrying the region of a gene involved in biosynthesis of pantothenic acid or a salt thereof or a part thereof, is used, and a method of producing D-pantoic acid or a salt thereof characterized by culturing a microbe resistant to salicylic acid, .alpha.-ketoisovaleric acid and/or .alpha.-ketobutyric acid and/or .alpha.-aminobutyric acid and/or .beta.-hydroxy-aspartic acid and/or O-methyl-threonine and capable of producing D-pantoic acid to accumulate D-pantoic acid or a salt thereof, which is then harvested, and in accordance with these methods, D-pantothenic acid, D-pantoic acid or salts thereof can be efficiently directly obtained microbiologically without using DL-pantoic acid, DL-pantolactone etc. as starting materials.