The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 14, 1996
Filed:
Jan. 19, 1995
Applicant:
Inventors:
Michael A Kuhn, Eugene, OR (US);
Richard P Haugland, Eugene, OR (US);
Assignee:
Molecular Probes, Inc., Eugene, OR (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; G01N / ; C08F / ;
U.S. Cl.
CPC ...
526263 ; 5262381 ; 5262382 ; 5262383 ; 527200 ; 527312 ; 528403 ; 528423 ; 530300 ; 530350 ; 536 173 ; 536 55 ; 536 551 ; 540467 ; 549223 ; 549224 ; 549227 ;
Abstract
This invention describes novel sensors for ions that are based on the combination of xanthylium-based dyes with metal-binding N,N'-diaryldiaza crown ethers. These sensors are primarily useful for detection and quantitation of alkali-metal ions in aqueous solution. Binding of the ion results in a change in the fluorescence properties of the indicating dye that can be correlated with the ion concentration. Methods are provided for attaching reactive groups on these sensors for conjugation to dyes, lipids and polymers and for enhancing entry of the indicators into living cells.