The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 07, 1996
Filed:
Feb. 03, 1995
Peter C Ulrich, Old Tappan, NJ (US);
Anthony Cerami, Shelter Island, NY (US);
Dilip R Wagle, Valley Cottage, NY (US);
Michael E Lankin, Montclair, NJ (US);
David H Shih, Lawrenceville, NJ (US);
San-Bao Hwang, Sudbury, MA (US);
The Rockefeller University, New York, NY (US);
Alteon Inc., Ramsey, NJ (US);
Abstract
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.