The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 30, 1996
Filed:
Jul. 02, 1992
Ruth M Ruprecht, Brookline, MA (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
A mammalian model system for the pathogenesis of lentiviral, especially HIV-1, infection during fetal gestation is disclosed. The model system is used in methods of testing various regimens for prophylaxis of fetal lentiviral infection. In the model system, fetal infection is established in a pregnant mammal (e.g., a rhesus monkey, Macaca mulatta or a pigtailed macaque, Macaca nemestrina) by ultrasound guided inoculation of an inoculum of a lentivirus, e.g., SIV, into the amniotic fluid. The testing methods include the analysis of the effectiveness of potential immunotherapeutic and transplacental drug therapy regimens. The model will also allow testing which viral isolates are pathogenic to the developing fetus.