The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 23, 1996

Filed:

Jul. 12, 1994
Applicant:
Inventors:

Philippe Cros, Lyons, FR;

Patrice A Allibert, Grezieu la Varenne, FR;

Bernard F Mandrand, Villeurbanne, FR;

Pascal T Dalbon, Venissieux, FR;

Assignee:

Bio Merieux, Marcy l'Etoile, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N / ; B01L / ;
U.S. Cl.
CPC ...
422104 ; 435-6 ; 436 94 ;
Abstract

In a process for immobilization by passive fixation on a solid support of a nucleic acid fragment containing less than 100 nucleotides, the fragment is deposited on the support in the form of a derivative. The derivative results from the covalent coupling of the fragment with a ligand having a molecular mass of less than 5,000 and containing at least one polar functional group. The derivative is not capable of forming a covalent bond with the support under the conditions of the deposition. When the ligand is a nucleotide or an oligonucleotide it is at least one nucleotide modified so as to introduce the polar functional group.


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