The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 1996
Filed:
Jun. 24, 1994
Applicant:
Inventors:
Lawrence J MacPherson, Hampton, NJ (US);
David T Parker, Livingston, NY (US);
Arco Y Jeng, Piscataway, NJ (US);
Assignee:
Ciba-Geigy Corporation, Tarrytown, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514336 ; 5142378 ; 514311 ; 514331 ; 514332 ; 514341 ; 514365 ; 514396 ; 514406 ; 514432 ; 514445 ; 514451 ; 514602 ; 514604 ; 546175 ; 546247 ; 546283 ; 546265 ; 546276 ; 546336 ; 546337 ; 544168 ; 548205 ; 5483351 ; 5483381 ; 549 13 ; 549 65 ; 549426 ; 564 84 ; 564 90 ; 564 92 ; 564 94 ;
Abstract
The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which comprises administering to a mammal in need thereof an effective macrophage metalloelastase inhibiting amount of a compound of formula I ##STR1## wherein Ar, R, R.sub.1 and R.sub.2 have meanings as defined, or of a pharmaceutically acceptable prodrug derivative thereof, or of a pharmaceutically acceptable salt thereof, or of pharmaceutical compositions comprising a said compound.