The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 1996
Filed:
Nov. 10, 1994
Hassan Salari, Ladner, CA;
Robert Bittman, Roslyn Heights, NY (US);
The University of British Columbia, Vancouver, CA;
Abstract
This invention pertains to the synthesis and usc as anti-cancer therapeutic agents of a group of substances with a glycerol backbone linked to phosphonocholinc, or other phosphorus-containing head groups, of the following formula: ##STR1## wherein n is 0 to 14 and R.sub.1 is an alkyl group containing 12 to 20 carbon atoms, R.sub.2 is a methyl group, n=0 to 14 and m=2 to 10, or enantiomer thereof, or mixture of stereoisomers. This invention also pertains to the following formula: ##STR2## wherein n is 15 to 17; R1 is an alkyl group: m is 0 to 2; T is an oxygen atom or a methylene; and R.sub.2 is a choline group and therapeutically effective pharmaceutically acceptable salts thereof. These thiophosphonolipids are useful for treating cancer in a mammal in need of cancer treatment.