The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 1996
Filed:
Mar. 05, 1991
Applicant:
Inventors:
Randy R Robinson, Los Angeles, CA (US);
Alvin Y Liu, Santa Monica, CA (US);
Jeffrey A Ledbetter, Seattle, WA (US);
Assignee:
XOMA Corporation, Berkeley, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; G01N / ;
U.S. Cl.
CPC ...
435-723 ; 4241331 ; 4241531 ; 4241551 ; 435-724 ; 435 7021 ; 4351722 ; 43524027 ; 5303873 ; 53038873 ;
Abstract
The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.
Published as:
PT86501A; ZA8891B; EP0274394A2; WO8804936A1; AU1189188A; DK499488A; DK499488D0; FI893300A7; FI893300L; EP0274394A3; HUT50869A; JPH02503143A; AU606653B2; NZ223120A; PT86501B; HU205383B; OA09734A; CA1336826C; US5500362A; US5677180A; US5721108A; US6120767A;