The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 1996
Filed:
Sep. 21, 1994
Hiroshi Akimoto, Kobe, JP;
Takenori Hitaka, Takarazuka, JP;
Takeda Chemical Industries, Ltd., Osaka, JP;
Abstract
The compounds of the formula, ##STR1## wherein the ring A is a pyrrole ring which may be hydrogenated; --B-- is a divalent cyclic or chain group which may be substituted; one of Q.sup.1 and Q.sup.2 is N, with the other being N or CH; W is a halogen or hydrogen atom or a group bonded to the bonding line with a carbon, nitrogen, oxygen or sulfur atom, provided that W is not --NH.sub.2 ; X is an amino, hydroxyl or mercapto group; Y is a hydrogen atom or a hydroxyl or amino group; Z is a straight-chain divalent group having a number of atoms of 2 to 5 composed of carbon atoms which each may be substituted, or carbon atoms which each may be substituted and one hetero atom which may be substituted; --COOR.sup.1 and --COOR.sup.2 each is the same as or different from the other and represents a carboxyl group which may be esterified, or salts thereof are provided. The compounds are produced by reacting compounds of the formula, ##STR2## wherein A, --B--, W, W, X, Y, Q.sup.1 and Q.sup.2 are the same as defined above, with compounds of the formula, ##STR3## wherein --COOR.sup.1 and --COOR.sup.2 are the same as defined above, and useful as anti-tumor agents.