The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 1996
Filed:
Sep. 29, 1993
Applicant:
Inventors:
Ralph A Rivero, Tinton Falls, NJ (US);
Peter D Williams, Harleysville, PA (US);
Daniel F Veber, Ambler, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514319 ; 514510 ; 514532 ; 514534 ; 514535 ; 514539 ; 514545 ; 514561 ; 514562 ; 514564 ; 514569 ; 514617 ; 514618 ; 514620 ; 514621 ; 514622 ; 514680 ; 514712 ; 514716 ; 514717 ; 514718 ; 514719 ; 514721 ; 514727 ; 514729 ; 514732 ; 560 10 ; 560 21 ; 560 23 ; 560 24 ; 560 25 ; 560 28 ; 560 52 ; 560 56 ; 560101 ; 560102 ; 564154 ; 564155 ; 564157 ; 564158 ; 564161 ; 564162 ; 564163 ; 564164 ; 564165 ; 564169 ; 564172 ; 568 31 ; 568 42 ; 568 43 ; 568 56 ; 568 58 ; 568306 ; 568326 ; 568585 ; 568586 ; 568632 ; 568633 ; 568634 ; 568659 ; 568660 ; 568661 ; 568662 ; 568705 ; 568808 ;
Abstract
Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.