The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 1996
Filed:
Aug. 25, 1993
Zdenko Prochazka, Prague, CS;
Ivo Blaha, Prague, CS;
Miroslava Zertova, Prague, CS;
Jirina Slaninova, Prague, CS;
Jiri Velek, Prague, CS;
Jana Skopkova, Prague, CS;
Michal Lebl, Prague, CS;
Tomislav Barth, Roztoky u Prahy, CS;
Lenka Maletinska, Prague, CS;
Hans Vilhardt, Espergarde, DK;
Ceskoslovenska akademie ved, , CS;
Abstract
Analogues of 8-D-homoarginine vasopressin were prepared with the general formula ##STR1## where X is L-O-methyltyrosine, L-p-ethylphenylalanine, D-p-ethylphenylalanine, L-p-methylphenylalanine or D-methylphenylalanine and R is cysteine or .beta.-mercaptopropionic acid. These vasopressin analogues exhibited an increased affinity to uterus receptors for oxytocin, where they acted as ocytocin antagonists. Moreover, the analogues of deamino vasopressin have a significantly reduced antidiuretic activity in comparison with [8-D-arginine]vasopressin.