The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 02, 1996
Filed:
Aug. 06, 1993
Applicant:
Inventors:
Assignees:
Shiseido Co., Ltd., , JP;
The General Hospital, , MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C12P / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
514-2 ; 435 691 ; 435 697 ; 435214 ; 435217 ; 514 12 ; 530300 ; 530324 ; 536 221 ; 536 231 ; 536 232 ; 536 234 ; 536 235 ; 536 241 ;
Abstract
A modified maxadilan protein exhibits higher biological activity than native maxadilan from the sand fly Lutzomyia longipalpis. A modified maxadilan fusion protein contains a thrombin cleavage site. This enables the production of the modified maxadilan as a fusion protein and recovery of the modified maxadilan after digestion with thrombin. The modified maxadilan is a potent vasodilator.