The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 12, 1995
Filed:
Aug. 19, 1993
Kimikazu Hashino, Takatsuki, JP;
Fusao Kimizuka, Ohmihachiman, JP;
Ikunoshin Kato, Uji, JP;
Yoshikazu Kurosawa, Nagoya, JP;
Koiti Titani, Kasugai, JP;
Kiyotoshi Sekiguchi, Sakai, JP;
Fujita Health University, both of, JP;
Takara Shuzo Co., Ltd., both of, JP;
Abstract
This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.