The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 05, 1995
Filed:
Jul. 14, 1994
Tibor Mezei, Budapest, HU;
Gabor Blasko, Budapest, HU;
Zoltan Budai, Budapest, HU;
Margit Csorgo, Budapest, HU;
Eva Furdyga, Budapest, HU;
Imre Klebovich, Budapest, HU;
Laszlo Koncz, Magyorod, HU;
Ilona Sztruhar, Budapest, HU;
Attila Mandi, Budapest, HU;
Kalman Nagy, Budapest, HU;
Klara Reiter nee Esses, Budapest, HU;
Gyula Simig, Budapest, HU;
Judit Szego, Budapest, HU;
Gyongyi Vereczkey nee Donath, Budapest, HU;
Egis Gyogyszergyar Rt., Budapest, HU;
Abstract
Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.