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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 5473066 B1

PDFFull Text
Date of Patent:
Dec. 05, 1995

Filed:

Jan. 19, 1994

Process for preparing benzothiazepine derivatives

Applicant:
Inventors:

Teruo Yamamori, Takarazuka, JP;

Hiroshi Harada, Toyonaka, JP;

Eiichi Oosugi, Kawanishi, JP;

Katsunori Sakai, Osaka, JP;

Assignee:

Shionogi & Co., Ltd., Osaka, JP;

Attorney:

Wenderoth, Lind & Ponack

Primary Examiner:

Mark L Berch

Int. Cl.
CPC ...
C07D / ; C07D / ; C07B / ;
U.S. Cl.
CPC ...
540491 ; 544 59 ; 544160 ; 544399 ; 546221 ; 5483355 ; 5483751 ; 548561 ; 548569 ; 560 17 ; 562431 ;
Abstract

Process for stereoselectivity preparing a cis-form of 5-(aminoalkylamino)-1,5-benzothiazepine derivative represented by formula (VI): ##STR1## is provided, said process comprising carrying out a stereoselective addition reaction of an o-(aminoalkylamino) thiophenyl derivative with a trans-substituted glycidic ester at an elevated temperature in a nonpolar solvent in the presence of a divalent or trivalent iron ion to prepare a threo-form intermediate, hydrolyzing the ester group of said intermediate, acetylating the hydroxyl group of said hydrolyzed compound, and subjecting said acetylated compound to a ring closure reaction to obtain the objective compound (VI).

Find Patent Forward Citations

Yamamori, Teruo. (1995). Process for preparing benzothiazepine derivatives (U.S. Patent No. 5473066). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/5473066

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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