The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 1995
Filed:
Jun. 22, 1993
James Burton, Jamaica Plain, MA (US);
Zhengxin Dong, Somerville, MA (US);
Timothy B Frigo, Watertown, MA (US);
The University Hospital, Boston, MA (US);
Abstract
The invention is directed to substrate analogs which are specific for tissue kallikrein. These analogs contain a sequence which corresponds to at least positions 388 to 390 of human kininogen, and which has a 4-aminophenylalanine (Phe(4NH.sub.2)), or a structurally or functionally similar residue, corresponding to position 389. These substrate analogs are useful in compositions and methods for the treatment or prevention of biological activities associated with tissue kallikrein including inflammation, the regulation of blood flow, the regulation of proenzyme activity through processing, shock, hypotension, vascular leakage, and the perception of pain.