The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 1995

Filed:

Jan. 25, 1993
Applicant:
Inventors:

Martinus A Groenen, Zetten, NL;

Annemarie E Veenstra, Vennep, NL;

Pieter Van Solingen, Naaldwijk, NL;

Bertus P Koekman, Schipluiden, NL;

Lucia H Van Der Voort, Delft, NL;

Juan F Martin, Leon, ES;

Santiago Gutierrez, Leon, ES;

Bruno Diez, Sebastian, ES;

Emilio Alvarez, Sevilla, ES;

Jose L Barredo, Trespaderne, ES;

Christina Esmahan, Bilbao, ES;

Assignee:

Gist-brocades N.V., Delft, NL;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P / ; C12N / ; C12N / ; C07H / ;
U.S. Cl.
CPC ...
435 691 ; 4351723 ; 4352521 ; 4352523 ; 4353201 ; 536 231 ; 536 234 ; 536 237 ;
Abstract

Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the antibiotic. The invention is exemplified with improved production of penicillin in Penicillium chrysogenum, with the isolation of another clustered biosynthetic gene(s) and with the expression of penicillin biosynthetic genes in Acremonium chrysogenum.


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