The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 17, 1995
Filed:
Oct. 07, 1994
Applicant:
Inventors:
Brian M Foxwell, Stockwell, London, SW9 9AY, GB;
Peter Parker, Surrey KT18 5DU, GB;
Andrew M Creighton, Mill Hill, London, NW7 3QY, GB;
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ;
U.S. Cl.
CPC ...
530328 ; 530345 ; 530402 ; 5303911 ;
Abstract
A method is provided for attaching .sup.32 P to a protein, normally an antibody, that will bind with and irradiate a tumor-associated structure leading to diagnostic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilizing .sup.32 P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.