The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 26, 1995

Filed:

Apr. 09, 1993
Applicant:
Inventors:

Amedeo Leonardi, Milan, IT;

Gianni Motta, Barlassina, IT;

Carlo Riva, Varese, IT;

Luciano Guarneri, Garbagnate Milanese, IT;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
549403 ; 549 21 ;
Abstract

A compound of the general formula: ##STR1## wherein X represents --CO--, --COO--, --CONH--, --CON(CH.sub.3)--, --CH.sub.2 NH--, --CH.sub.2 N(CH.sub.3)--, --CH.sub.2 NHCO--, --CH.sub.2 N(CH.sub.3)CO--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, or --CH.sub.2 SO.sub.2 --; n represents an integer from 1 to 4; and B represents one of the following groups: ##STR2## wherein R.sub.1 represents a lower alkyl (C.sub.1 -C.sub.4) group; R.sub.2 represents a hydrogen atom or a lower alkyl (C.sub.1 -C.sub.4) group; R.sub.3 represents a hydrogen atom or OR.sub.4 group wherein R.sub.4 represents a lower alkyl (C.sub.1 -C.sub.4) group; p represents an integer from 1 to 3; and Y represents a valence bond (Y1), or one of the following groups: ##STR3## wherein R.sub.2 is as above defined as well as the enantiomers, diastereomers, N-oxides, prodrugs, metabolites, prodrugs of metabolites, and pharmaceutically acceptable salts of these compounds. The compounds are long-lasting antispasmodic therapeutic agents and are particularly useful for the treatment of lower urinary tract disorders.


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