The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 19, 1995
Filed:
Nov. 28, 1994
Carlos M Ferrario, Winston-Salem, NC (US);
Robson A Santos, Shaker Heights, OH (US);
Kay B Brosnihan, Winston-Salem, NC (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
The present invention is directed to a process for treating hypertension in mammals through the administration of an effective amount of a Z-Pro-prolinal (ZPP) composition. In addition, the present invention is also directed to a pharmaceutical composition for treating hypertension in mammals comprised of an active ingredient, Z-Pro-prolinal (ZPP). It has recently been discovered that Z-Pro-prolinal (ZPP) is a useful inhibitor to the biosynthetic formation of Ang(1-7), a previously unknown biologically active hypertensive agent in the reninangiotensin system (RAS). By administering an effective amount of Z-Pro-prolinal (ZPP), Ang-(1-7) formation may be reduced, resulting in a significant decrease in blood pressure without notable changes in heart rate and other circulatory functions.