The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 05, 1995
Filed:
Mar. 17, 1994
Applicant:
Inventors:
Michael J Broadhurst, Barley, GB;
Paul A Brown, Hitchin, GB;
William H Johnson, Hitchin, GB;
Geoffrey Lawton, Hitchin, GB;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ;
U.S. Cl.
CPC ...
5142282 ; 514212 ; 5142278 ; 5142352 ; 514253 ; 514323 ; 514326 ; 5142305 ; 514417 ; 5142362 ; 5142358 ; 5142355 ;
Abstract
Hydroxamic acid derivatives of the fdrrnula ##STR1## and pharmaceutically acceptable salts thereof, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases, such as, rheumatoid arthritis and ostecarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis, are described. Said compounds can be prepared either by hyclroxamidating a corresponding carboxylic acid or deprotecting a corresponding benzyloxycarbamoyl compound.