The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 1995
Filed:
Sep. 16, 1993
Reijo J Backstrom, Helsinki, FI;
Kalevi E Heinola, Jarvempaa, FI;
Erkki J Honkanen, Vantaa, FI;
Seppo K Kaakkola, Helsinki, FI;
Pekka J Kairisalo, Helsinki, FI;
Inge-Britt Y Linden, Helsinki, FI;
Pekka I Mannisto, Helsinki, FI;
Erkki A Nissinen, Espoo, FI;
Pentti Pohto, Helsinki, FI;
Aino K Pippuri, Espoo, FI;
Jarmo J Pystynen, Espoo, FI;
Orion-yhtyma Oy, Espoo, FI;
Abstract
A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.