The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 1995
Filed:
Oct. 12, 1990
Applicant:
Inventors:
Todd K Jones, Edison, NJ (US);
Sander G Mills, Woodbridge, NJ (US);
David Askin, Edison, NJ (US);
Robert A Reamer, Bloomfield, NJ (US);
Richard Desmond, Metuchen, NJ (US);
David M Tschaen, Aberdeen, NJ (US);
Ralph P Volante, East Windsor, NJ (US);
Ichiro Shinkai, Westfield, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07F / ;
U.S. Cl.
CPC ...
546 14 ; 546245 ; 548110 ; 548229 ; 556 12 ; 564463 ; 564305 ; 560 45 ; 560174 ; 560 51 ; 549-4 ; 540456 ; 540452 ;
Abstract
A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.