The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 22, 1995
Filed:
Nov. 16, 1992
Applicant:
Inventors:
Flemming S Vassbotn, Uppsala, SE;
Maria Andersson, Uppsala, SE;
Gudrun Backstrom, Uppsala, SE;
Ulla Engstrom, Uppsala, SE;
Carl-Henrik Heldin, Uppsala, SE;
Ulf Hellman, Uppsala, SE;
Arne stman, Uppsala, SE;
Bengt Westermark, Uppsala, SE;
Assignee:
Ludwig Institute for Cancer Research, New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
530324 ; 530325 ; 530326 ; 530327 ; 530399 ; 530402 ; 530408 ; 530350 ; 930120 ;
Abstract
The invention describes antagonists for PDGF. The antagonists contain amino acids, and may be monomers or dimers. Especially preferred are dimers which bind the PDGF receptors, but prevent dimerization of the bound receptors. Dimerization is necessary for PDGF effect, hence the antagonistic effect. Also described are nucleic acid sequences for making the antagonists, as well as cell lines transfected with the material.